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Kevin J Lenton, Alain T Sané, Hélène Therriault, André M Cantin, Hélène Payette, J Richard Wagner - Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency - Am J Clin Nutr - 2003 Jan

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The most harmful scenario is having gene variants that reduce glutathione levels and high toxin levels that deplete glutathione